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Cell transplantation for endocrine disorders.

M K Lee1, Y H Bae

  • 1Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 135-710, Seoul, South Korea. mklee@smc.samsung.co.kr

Advanced Drug Delivery Reviews
|August 16, 2000
PubMed
Summary

Cell transplantation offers a more physiological approach to treating endocrine disorders than hormone replacement therapy. Immunoisolation techniques show promise in overcoming transplant rejection, advancing treatments for conditions like diabetes.

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Area of Science:

  • Endocrinology and immunology
  • Regenerative medicine
  • Transplantation science

Background:

  • Current hormone replacement therapy (HRT) inadequately mimics complex endogenous hormone interactions.
  • Organ or cell transplantation presents a more physiological treatment strategy for endocrine disorders.
  • Allotransplantation faces significant limitations due to immune rejection, hindering widespread clinical application.

Purpose of the Study:

  • To review advancements in organ and cell transplantation for endocrine disorders.
  • To explore immunoisolation as a method to overcome transplant rejection.
  • To provide perspectives on future directions in endocrine cell transplantation.

Main Methods:

  • Review of existing literature on organ and cell transplantation for endocrine disorders.

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  • Analysis of immunomanipulation strategies, focusing on immunoisolation.
  • Examination of clinical outcomes for immunoisolated cell transplants.

    • Main Results:

    • Significant progress has been made in endocrine cell transplantation, particularly in recent years.
    • Immunoisolation is a key strategy to mitigate immune rejection in allotransplantation.
    • Human islet cell transplantation shows potential for curing diabetes; other endocrine cell transplantations (parathyroid, thyroid, adrenal) were also discussed.

    Conclusions:

    • Endocrine cell transplantation, especially using immunoisolation, is a promising avenue for treating endocrine disorders.
    • Further research and development in immunoisolation techniques are crucial for broader clinical adoption.
    • Human islet cell transplantation represents a significant advancement in diabetes management.