Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Candida adherence phenomena, from commensalism to pathogenicity.

J M Senet1

  • 1Laboratoire d'Immunologie, Faculté de Pharmacie, Université d'Angers, France. senet@univ-angers.fr

International Microbiology : the Official Journal of the Spanish Society for Microbiology
|December 8, 2000
PubMed
Summary

Candida cell surface molecules are crucial for host adherence and candidiasis development. Changes in these molecules, influenced by host conditions, may drive the shift from harmless to pathogenic states.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Susceptibilities of Cryptococcus neoformans strains to platelet binding in vivo and to the fungicidal activity of thrombin-induced platelet microbicidal proteins in vitro.

Infection and immunity·2001
Same author

[Infection and cancer: general information and specific questions].

Presse medicale (Paris, France : 1983)·2000
Same author

[Standards, options and recommendations for good practice in hemoculture in cancerology].

Presse medicale (Paris, France : 1983)·2000
Same author

[Standards, Options and Recommendations (SOR) for the surveillance and the prevention of cross infections in oncology. Fédération Nationale des Centres de Lutte Contre le Cancer].

Bulletin du cancer·2000
Same author

Production and characterization of two monoclonal antibodies specific for Plasmopara halstedii.

Applied and environmental microbiology·2000
Same author

Adherence of platelets to Candida species in vivo.

Infection and immunity·2000

Area of Science:

  • Medical Mycology
  • Pathogen-Host Interactions
  • Cell Biology

Background:

  • The external layers of Candida cells contain molecules vital for adhering to host surfaces.
  • These surface molecules play a key role in the development of candidiasis.
  • Known receptors for extracellular matrix components like fibrinogen and fibronectin exist on Candida surfaces.

Purpose of the Study:

  • To investigate the role of Candida cell surface molecules in host interactions.
  • To understand how host conditions influence the expression of these surface molecules.
  • To explore the link between surface molecule changes and the transition to pathogenicity.

Main Methods:

  • Analysis of Candida cell surface protein expression.
  • Investigation of interactions with host extracellular matrix components.

Related Experiment Videos

  • Correlation of surface molecule changes with host conditions and pathogenicity.

    • Main Results:

    • Candida cell surface molecules are essential for adherence to host tissues.
    • Expression of surface receptors can be altered by host conditions.
    • These alterations are significant in the transition from commensal to pathogenic behavior.

    Conclusions:

    • Surface proteins are critical for Candida's interaction with host defense mechanisms.
    • Modulation of surface molecules by the host environment is a key factor in candidiasis.
    • Targeting these surface molecules could offer strategies for controlling candidiasis.