Related Experiment Videos
Polymeric colloidal systems containing ethionamide: preparation and physico-chemical characterization.
E Lopes1, A R Pohlmann, V Bassani
1Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Brazil.
Die Pharmazie
|August 17, 2000
Summary
Ethionamide association with nanocapsules (NC) and nanospheres (NS) was evaluated. Nanoparticle formulation significantly impacts ethionamide release, with post-preparation incorporation (A) enhancing drug release from NC and NS.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Drug Delivery Systems
Background:
- Ethionamide is a crucial drug for tuberculosis treatment.
- Developing effective drug delivery systems is essential for improving therapeutic outcomes.
Purpose of the Study:
- To evaluate the association of ethionamide with different colloidal systems.
- To investigate the impact of preparation methods on ethionamide encapsulation and release.
Main Methods:
- Preparation of nanocapsules (NC), nanospheres (NS), and nanoemulsions (NE) using interfacial deposition and spontaneous emulsification.
- Incorporation of ethionamide before (B) and after (A) nanoparticle preparation.
- Characterization of particle size, zeta potential, drug association, and in vitro drug release.
Main Results:
- All formulations, except NE, showed acceptable particle size distribution.
- Zeta potential ranged from -36.6 mV to -46.1 mV, indicating formulation stability.
- Nanocapsules (NC) exhibited higher ethionamide association percentages (62.4% B, 56.2% A) compared to nanospheres (NS) and nanoemulsions (NE).
- Drug release was faster from NC and NS prepared by procedure A (post-incorporation).
- Ethionamide was primarily adsorbed on the nanoparticle surface, with some encapsulation in NC (10%) and NS (20%).
Conclusions:
- Colloidal system choice and preparation method significantly influence ethionamide association and release kinetics.
- Nanocapsules and nanospheres show potential as effective delivery systems for ethionamide.
- Further studies are warranted to optimize these systems for enhanced therapeutic efficacy.