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[Inhibitory effect of suplatast tosilate on eosinophil migration]
Y Kobayashi1, M Nagata, H Yamamoto
1Second Department of Internal Medicine, Saitama Medical School.
Arerugi = [Allergy]
|August 17, 2000
Summary
Suplatast tosilate inhibits eosinophil migration induced by inflammatory mediators like platelet-activating factor (PAF) and interleukin-5 (IL-5). This suggests a mechanism for its effectiveness in treating allergic diseases by reducing eosinophil infiltration.
Area of Science:
- Immunology
- Pharmacology
Context:
- Suplatast tosilate is used for allergic diseases, potentially by reducing eosinophil infiltration in airways.
- The precise mechanism by which suplatast tosilate affects eosinophils is not fully understood.
Purpose:
- To investigate if suplatast tosilate directly inhibits eosinophil migration in response to inflammatory mediators in vitro.
- To elucidate the mechanism of action of suplatast tosilate in allergic inflammation.
Summary:
- Suplatast tosilate did not affect spontaneous eosinophil migration.
- Eosinophil migration induced by platelet-activating factor (PAF) was significantly inhibited by suplatast tosilate.
- Interleukin-5 (IL-5)-induced eosinophil migration was also inhibited by suplatast tosilate.
Impact:
- Suplatast tosilate inhibits eosinophil locomotion in response to PAF and IL-5.
- These findings suggest a direct mechanism for suplatast tosilate in attenuating eosinophil infiltration during allergic inflammation.