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[Microgravity and autonomic nervous system].

S Iwase1, T Mano

  • 1Department of Autonomic Neuroscience, Nagoya University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|August 17, 2000
PubMed
Summary
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Microgravity significantly impacts autonomic nervous system function, suppressing muscle sympathetic nerve activity (MSNA). These changes may contribute to cardiovascular deconditioning experienced by astronauts after spaceflight.

Area of Science:

  • Physiology
  • Neuroscience
  • Aerospace Medicine

Context:

  • Microgravity poses challenges to autonomic nervous system regulation.
  • Spaceflight induces neuro-vestibular changes and fluid shifts, leading to space motion sickness and cardiovascular deconditioning.
  • Understanding these effects is crucial for astronaut health and mission success.

Purpose:

  • To investigate the influence of microgravity on autonomic function, specifically muscle sympathetic nerve activity (MSNA).
  • To analyze MSNA responses under various simulated and actual microgravity conditions.
  • To correlate MSNA alterations with cardiovascular deconditioning observed post-spaceflight.

Summary:

  • Microgravity exposure, through parabolic flight and water immersion, significantly suppressed MSNA.

Related Experiment Videos

  • Prolonged simulated microgravity (bed rest, dry immersion) showed varied effects on MSNA, with some studies indicating enhancement.
  • Observed alterations in MSNA are linked to the development of cardiovascular deconditioning and orthostatic intolerance in astronauts.

    • Impact:

    • Provides insights into the mechanisms underlying space motion sickness and cardiovascular deconditioning.
    • Highlights the importance of monitoring autonomic function during and after space missions.
    • Informs the development of countermeasures to mitigate the adverse effects of microgravity on the human body.