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Related Experiment Videos

Intestinal elimination of hydroxyethyl starch?

K Lenz1, W Schimetta, W Pölz

  • 1Department of Internal Medicine, Konventspital Barmherzige Brüder, Linz, Austria. kurt.lenz@univie.ac.at

Intensive Care Medicine
|August 17, 2000
PubMed
Summary
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Hydroxyethyl starch (HES) is primarily cleared by the kidneys. This study found minimal intestinal excretion of HES 200/0.5, suggesting further research is needed to understand its complete elimination pathway.

Area of Science:

  • Pharmacology
  • Nephrology
  • Gastroenterology

Background:

  • Hydroxyethyl starch (HES) is a colloid plasma volume expander.
  • Renal excretion is the primary elimination route for HES.
  • Extrarenal elimination pathways for HES remain poorly understood.

Purpose of the Study:

  • To quantify the intestinal excretion of infused Hydroxyethyl starch (HES) 200/0.5.
  • To compare the recovery rates of HES in urine and plasma.
  • To investigate potential extrarenal elimination routes for HES.

Main Methods:

  • Prospective clinical study involving six healthy male volunteers.
  • Intravenous administration of 500 ml of 10% HES 200/0.5.
  • Continuous gut lavage to facilitate sample collection and analysis of fecal and urinary HES excretion.

Related Experiment Videos

Main Results:

  • Minimal HES excretion (approximately 0.2%) was detected in feces.
  • Urinary recovery rates of HES were approximately 30% at 6 hours and 40% at 14 hours post-infusion.
  • Total HES recovery in urine and plasma was around 50% of the administered dose within 14 hours.

Conclusions:

  • HES 200/0.5 is negligibly excreted via the intestine in individuals with a healthy gut.
  • The study highlights the need for further investigation into the complete metabolic fate and elimination of HES.
  • Approximately 50% of the administered HES dose's fate remains unaccounted for, necessitating further research.