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A Decellularization Methodology for the Production of a Natural Acellular Intestinal Matrix
Published on: October 7, 2013
Intestinal elimination of hydroxyethyl starch?
1Department of Internal Medicine, Konventspital Barmherzige Brüder, Linz, Austria. kurt.lenz@univie.ac.at
Intensive Care Medicine
|August 17, 2000
Summary
Hydroxyethyl starch (HES) is primarily cleared by the kidneys. This study found minimal intestinal excretion of HES 200/0.5, suggesting further research is needed to understand its complete elimination pathway.
Area of Science:
- Pharmacology
- Nephrology
- Gastroenterology
Background:
- Hydroxyethyl starch (HES) is a colloid plasma volume expander.
- Renal excretion is the primary elimination route for HES.
- Extrarenal elimination pathways for HES remain poorly understood.
Purpose of the Study:
- To quantify the intestinal excretion of infused Hydroxyethyl starch (HES) 200/0.5.
- To compare the recovery rates of HES in urine and plasma.
- To investigate potential extrarenal elimination routes for HES.
Main Methods:
- Prospective clinical study involving six healthy male volunteers.
- Intravenous administration of 500 ml of 10% HES 200/0.5.
- Continuous gut lavage to facilitate sample collection and analysis of fecal and urinary HES excretion.
Main Results:
- Minimal HES excretion (approximately 0.2%) was detected in feces.
- Urinary recovery rates of HES were approximately 30% at 6 hours and 40% at 14 hours post-infusion.
- Total HES recovery in urine and plasma was around 50% of the administered dose within 14 hours.
Conclusions:
- HES 200/0.5 is negligibly excreted via the intestine in individuals with a healthy gut.
- The study highlights the need for further investigation into the complete metabolic fate and elimination of HES.
- Approximately 50% of the administered HES dose's fate remains unaccounted for, necessitating further research.
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