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Time course of oxidative stress after major burns
M Bertin-Maghit1, J Goudable, E Dalmas
1Centre des Brulés, Hôpital E. Herriot, Lyon, France. marc.bertin-maghit@chu-lyon.fr
Objective:
To evaluate oxidative stress resulting from major burns in humans.
Design:
Prospective clinical study with control group.
Setting:
Mechanically ventilated adult patients admitted with more than 30% total burn surface area.
Patients And Participants:
20 patients with a mean body surface burned area of 54%.
Measurements And Results:
The oxidative stress evaluation was based on measurements of trace elements, vitamins, antioxidant enzymatic activity and end-products of lipid peroxidation. During the first 5 days after injury burn patients exhibit a decrease in selenium and antioxidant vitamins (C, beta-carotene, lycopene) and an increase in lipid peroxidation products (TBARS).
Conclusion:
Our results suggest that major burn is associated with oxidative stress during the 5 days after the initial injury, as demonstrated by a simultaneous decrease in antioxidant vitamins and a large increase in TBARS.
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