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Comparing filtered backprojection and ordered-subsets expectation maximization for small-lesion detection and

R G Wells¹, M A King, P H Simkin

¹Division of Nuclear Medicine, University of Massachusetts Medical Center, Worcester 01655, USA.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine

|August 17, 2000

Summary

Ordered-subsets expectation maximization (OSEM) with attenuation correction (AC) may improve the detection and localization of thoracic gallium lesions compared to filtered backprojection (FBP). Further research is needed to confirm these findings in clinical settings.

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Area of Science:

Nuclear Medicine
Medical Imaging Analysis

Background:

Iterative reconstruction (IR) methods like ordered-subsets expectation maximization (OSEM) are emerging alternatives to filtered backprojection (FBP) for single-photon emission computed tomography (SPECT) image reconstruction.
Conflicting evidence exists regarding the diagnostic performance improvement of IR over FBP.

Purpose of the Study:

To compare the diagnostic performance of OSEM versus FBP for detecting and localizing small lesions in simulated thoracic gallium SPECT images.
To evaluate the impact of attenuation correction (AC) on lesion detection and localization accuracy for both OSEM and FBP.

Main Methods:

Simulated thoracic gallium SPECT images were generated using an analytic projector and a cardiac torso phantom.
Lesion detection and localization accuracy were assessed using localization receiver operating characteristic (LROC) methodology by 5 nuclear medicine physicians.
Statistical analysis involved two-way ANOVA and Scheffé multiple comparisons test.

Main Results:

Filtered backprojection (FBP) with or without attenuation correction (AC) showed minimal differences in lesion detection and localization accuracy.
Ordered-subsets expectation maximization (OSEM) with AC significantly extended the contrast range for accurate lesion detection and localization.
No significant difference in reconstruction accuracy was observed between OSEM and FBP when AC was not applied.

Conclusions:

OSEM with AC demonstrates potential for improved detection and localization of thoracic gallium-labeled lesions compared to FBP reconstruction.
The findings suggest that OSEM with AC may enhance diagnostic performance in specific clinical scenarios.