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Related Experiment Videos

Oncotic pressure in solid tumors is elevated.

M Stohrer1, Y Boucher, M Stangassinger

  • 1Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA.

Cancer Research
|August 17, 2000
PubMed
Summary
This summary is machine-generated.

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Tumor interstitial fluid has high oncotic pressure, similar to plasma, due to leaky tumor vessels. This finding impacts the delivery of large therapeutic agents to cancer cells.

Area of Science:

  • Oncology
  • Biophysics
  • Vascular Biology

Background:

  • Fluid and macromolecule movement across microvessels is governed by oncotic and hydrostatic pressures.
  • Tumor interstitial fluid pressure is elevated, nearing microvascular pressure.
  • Oncotic pressure data for tumor interstitial fluid is lacking.

Purpose of the Study:

  • To investigate the oncotic pressure within tumor interstitial fluid.
  • To test the hypothesis that tumor interstitial oncotic pressure is similar to plasma oncotic pressure.

Main Methods:

  • Developed a chronic wick method for direct measurement of interstitial fluid oncotic pressure in mouse tumor models.
  • Measured oncotic pressures in four human tumor xenografts (rhabdomyosarcoma, squamous cell carcinoma, small cell lung carcinoma, colon adenocarcinoma), subcutaneous tissue, and plasma.

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Main Results:

  • Interstitial oncotic pressures in tumors ranged from 16.7 to 24.2 mm Hg, significantly higher than subcutaneous tissue (8.2 mm Hg).
  • Tumor interstitial oncotic pressures were comparable to plasma oncotic pressure (20.0 mm Hg).
  • The oncotic pressure difference across the tumor microvascular wall was found to be low.

Conclusions:

  • The study supports the hypothesis of similar oncotic pressures in tumor interstitium and plasma.
  • High tumor interstitial oncotic pressure, alongside elevated interstitial fluid pressure, contributes to poor delivery of large therapeutic agents.
  • Understanding these pressure dynamics is crucial for improving cancer therapy efficacy.