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[Late results of replacement of the antrio-ventricular valve]
Insights
Allografts for mitral valve replacement showed initial success but deteriorated over time. Due to poor long-term durability, this method is no longer used for mitral valve surgery.
Area of Science:
- Cardiovascular Surgery
- Transplantation Immunology
Background:
- Mitral valve replacement is a critical cardiac procedure.
- Allografts offer a biological option for valve replacement.
Purpose of the Study:
- To evaluate the long-term efficacy and durability of allografts for mitral and tricuspid valve replacement.
Main Methods:
- Implantation of mitral-valve-allografts in 11 patients and tricuspid valve allografts in 2 patients between 1966 and 1969.
- Postoperative monitoring and long-term follow-up.
Main Results:
- Initial function was good in most cases (8 mitral, 1 tricuspid).
- No thromboembolic complications were observed.
- All allografts eventually showed late functional deterioration.
- Four allografts required re-replacement; four remained functional 4-6 years post-op.
Conclusions:
- While initially functional, mitral valve allografts exhibit poor long-term durability.
- Late deterioration limits the clinical utility of allografts for mitral valve replacement.
- This technique is no longer employed due to unsatisfactory long-term outcomes.
Abstract:
From 1966 to 1969 mitral-valve-allografts have been implanted for mitral valve replacement in 11 and for tricuspid valve replacement in two patients. Three patients died immediately after the operation. Eigth allografts in mitral position and one in tricuspid position functioned well. One case was complicated by candida albicans. There were no thromboembolic complications. Long-term follow up revealed late deterioration of allograft function in every case. Four allografts have been replaced four are still functioning four to six years postoperatively. Because of the poor durability of the results this method of mitral valve replacement is not used any more.