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Updated: Jul 18, 2026
05:51
A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
Published on: May 6, 2014
Lipoxygenases and atherosclerosis: protection versus pathogenesis
1Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. cathcam@ccf.org
Free Radical Biology & Medicine
|August 18, 2000
Summary
This review explores how 15 lipoxygenase (15LO) in monocyte-macrophages contributes to oxidized lipids in atherosclerosis. It examines 15LO
Area of Science:
- Biochemistry
- Cardiovascular Research
- Cell Biology
Background:
- 15 lipoxygenase (15LO) is an enzyme implicated in lipid oxidation within atherosclerotic lesions.
- Monocyte-macrophages are identified as the primary cells expressing 15LO in these lesions.
Purpose of the Study:
- To review evidence linking 15LO to atherogenesis.
- To evaluate mechanisms by which 15LO in monocyte-macrophages oxidizes LDL.
- To explore the pro- and anti-atherogenic roles of 15LO oxidation products.
Main Methods:
- Review of existing scientific literature on 15LO and atherosclerosis.
- Analysis of pathways regulating 15LO expression and activity.
Main Results:
- Evidence supports 15LO's role in the formation of oxidized lipids in atherosclerotic plaques.
- Potential mechanisms for LDL oxidation by 15LO-expressing monocyte-macrophages are discussed.
- Diverse functions of 15LO lipid oxidation products in atherogenesis are outlined.
Conclusions:
- 15LO plays a significant role in atherogenesis through lipid oxidation.
- Understanding 15LO regulation offers potential therapeutic targets for cardiovascular disease.
- Further research into 15LO's complex functions is warranted.
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