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Decrease in carotid intima-media thickness after 1-year therapy with etidronate for osteopenia associated with type 2

H Koshiyama1, Y Nakamura, S Tanaka

  • 1Department of Internal Medicine, Hyogo Prefectural Amagasaki Hospital, Japan.

The Journal of Clinical Endocrinology and Metabolism
|August 18, 2000
PubMed
Summary

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Etidronate treatment may reduce atherosclerosis in type 2 diabetes patients. This study found a significant decrease in carotid artery intima-media thickness after one year of etidronate therapy, suggesting potential antiatherogenic effects.

Area of Science:

  • Cardiovascular research
  • Endocrinology
  • Pharmacology

Background:

  • Bisphosphonates show potential antiatherogenic effects in preclinical studies.
  • Human data on bisphosphonates' impact on atherosclerosis are lacking.
  • Type 2 diabetes is associated with increased cardiovascular risk.

Purpose of the Study:

  • To investigate the effect of etidronate on carotid arterial intima-media thickness in humans.
  • To assess the antiatherogenic potential of etidronate in patients with type 2 diabetes and osteopenia.

Main Methods:

  • Prospective study involving 57 patients with type 2 diabetes and osteopenia.
  • Treatment group received cyclical etidronate (200 mg/day for 2 weeks every 3 months) for 1 year.
  • Intima-media thickness measured and compared to a control group.

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Main Results:

  • Etidronate treatment led to a significant decrease in carotid intima-media thickness (0.038 +/- 0.011 mm).
  • The decrease in intima-media thickness was significantly greater compared to the control group (P < 0.005).
  • No significant changes were observed in cardiovascular parameters.

Conclusions:

  • Etidronate may possess antiatherogenic properties in patients with type 2 diabetes.
  • Clinical dosage of etidronate could be beneficial in managing atherosclerosis progression in this population.
  • Further research is needed to elucidate the underlying mechanisms of etidronate's antiatherogenic action.