Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lactate improves cardiac efficiency after hemorrhagic shock.

J A Kline1, L R Thornton, G D Lopaschuk

  • 1Department of Emergency Medicine, Carolinas Medical Center, Charlotte, North Carolina 28232-2861, USA.

Shock (Augusta, Ga.)
|August 18, 2000
PubMed
Summary

Lactate enhances cardiac function and efficiency in hearts recovering from hemorrhagic shock by improving energy metabolism. This study shows lactate benefits cardiac work and efficiency when free fatty acids are present.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polyphenic risk score shows robust predictive ability for long-term future suicidality.

Discover mental health·2022
Same author

Ruling out pulmonary embolism across different subgroups of patients and healthcare settings: protocol for a systematic review and individual patient data meta-analysis (IPDMA).

Diagnostic and prognostic research·2019
Same author

Maternal high fat diet induces early cardiac hypertrophy and alters cardiac metabolism in Sprague Dawley rat offspring.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2018
Same author

Vascular smooth muscle desensitization in rabbit epigastric and mesenteric arteries during hemorrhagic shock.

American journal of physiology. Heart and circulatory physiology·2016
Same author

Mitochondrial pharmacology: energy, injury and beyond.

British journal of pharmacology·2014
Same author

Treatment of submassive pulmonary embolism with tenecteplase or placebo: cardiopulmonary outcomes at 3 months: multicenter double-blind, placebo-controlled randomized trial.

Journal of thrombosis and haemostasis : JTH·2014

Area of Science:

  • Cardiovascular Physiology
  • Metabolic Biochemistry
  • Shock Pathophysiology

Background:

  • Severe acute hemorrhagic shock significantly impairs cardiac function and energy metabolism.
  • Understanding metabolic interventions to support the heart during shock recovery is crucial.

Purpose of the Study:

  • To investigate the role of lactate in improving cardiac function and metabolism following severe acute hemorrhagic shock.
  • To determine if lactate supplementation can enhance energy substrate utilization in the compromised heart.

Main Methods:

  • Isolated working rat heart model subjected to hemorrhagic shock.
  • Perfusion with various substrate combinations including glucose, palmitate, and lactate.
  • Measurement of cardiac work, efficiency, and myocardial metabolic intermediates (CoA, acetyl CoA, succinyl CoA).

Related Experiment Videos

  • Assessment of pyruvate dehydrogenase (PDH) activity.

    • Main Results:

    • Lactate significantly improved cardiac work and efficiency in shocked hearts, particularly when co-administered with palmitate.
    • Shocked hearts showed reduced PDH activity compared to controls.
    • Lactate increased succinyl CoA levels in shocked hearts, suggesting tricarboxylic acid cycle anaplerosis.
    • Lactate did not increase acetyl CoA content in shocked hearts.

    Conclusions:

    • Lactate plays a beneficial role in the recovery of cardiac function after severe hemorrhagic shock.
    • Lactate improves myocardial efficiency by potentially enhancing tricarboxylic acid cycle substrate availability in the presence of free fatty acids.
    • Lactate represents a promising metabolic substrate for supporting the heart during shock resuscitation.