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Related Experiment Videos

Heparin-coated stents.

J F Kocsis1, G Llanos, E Holmer

  • 1Cordis, a Johnson & Johnson Company, Warren, NJ 07059, USA.

Journal of Long-Term Effects of Medical Implants
|August 18, 2000
PubMed
Summary

Heparin-coated stents, featuring the Carmeda BioActive Surface (CBAS), were developed to reduce stent thrombosis and bleeding complications. Studies evaluated their preclinical thromboresistance and clinical effectiveness in interventional cardiology.

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Area of Science:

  • Interventional Cardiology
  • Biomaterials Science

Background:

  • Coronary stenting has advanced cardiovascular interventions but carries risks of stent thrombosis and bleeding due to anticoagulation.
  • Reducing stent surface thrombogenicity is a key strategy to mitigate these complications.

Purpose of the Study:

  • To evaluate the Carmeda BioActive Surface (CBAS), a heparin coating, for its ability to enhance stent thromboresistance.
  • To review preclinical and clinical data on heparin-coated stents in various cardiovascular settings.

Main Methods:

  • Coating of Cordis stents with the patented Carmeda BioActive Surface (CBAS) heparin technology.
  • Preclinical testing of stent thromboresistance.
  • Analysis of clinical studies involving heparin-coated stents.

Main Results:

  • Heparin coating aims to decrease stent thrombogenicity.
  • Preclinical evaluations demonstrated thromboresistance.
  • Clinical studies assessed efficacy and safety in diverse patient populations.

Conclusions:

  • Heparin-coated stents represent a strategy to improve safety and efficacy in interventional cardiology.
  • The Carmeda BioActive Surface (CBAS) technology has been applied to reduce thrombotic and hemorrhagic complications associated with coronary stents.

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