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Related Experiment Videos

Heparin-coated stents.

J F Kocsis1, G Llanos, E Holmer

  • 1Cordis, a Johnson & Johnson Company, Warren, NJ 07059, USA.

Journal of Long-Term Effects of Medical Implants
|August 18, 2000
PubMed
Summary
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Heparin-coated stents, featuring the Carmeda BioActive Surface (CBAS), were developed to reduce stent thrombosis and bleeding complications. Studies evaluated their preclinical thromboresistance and clinical effectiveness in interventional cardiology.

Area of Science:

  • Interventional Cardiology
  • Biomaterials Science

Background:

  • Coronary stenting has advanced cardiovascular interventions but carries risks of stent thrombosis and bleeding due to anticoagulation.
  • Reducing stent surface thrombogenicity is a key strategy to mitigate these complications.

Purpose of the Study:

  • To evaluate the Carmeda BioActive Surface (CBAS), a heparin coating, for its ability to enhance stent thromboresistance.
  • To review preclinical and clinical data on heparin-coated stents in various cardiovascular settings.

Main Methods:

  • Coating of Cordis stents with the patented Carmeda BioActive Surface (CBAS) heparin technology.
  • Preclinical testing of stent thromboresistance.
  • Analysis of clinical studies involving heparin-coated stents.

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Main Results:

  • Heparin coating aims to decrease stent thrombogenicity.
  • Preclinical evaluations demonstrated thromboresistance.
  • Clinical studies assessed efficacy and safety in diverse patient populations.

Conclusions:

  • Heparin-coated stents represent a strategy to improve safety and efficacy in interventional cardiology.
  • The Carmeda BioActive Surface (CBAS) technology has been applied to reduce thrombotic and hemorrhagic complications associated with coronary stents.