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Tracheal intubating conditions after induction with sevoflurane 8% in children. A comparison with two intravenous

J M Blair1, D A Hill, I M Bali

  • 1The Ulster Hospital, Dundonald, Belfast, UK.

Anaesthesia
|August 18, 2000
PubMed

Insights

Sevoflurane inhalation provided satisfactory tracheal intubating conditions in children, comparable to propofol with succinylcholine. This offers a safe alternative for pediatric anesthesia induction.

Area of Science:

  • Anesthesiology
  • Pediatric Medicine
  • Pharmacology

Background:

  • Optimizing tracheal intubation conditions is crucial for pediatric anesthesia.
  • Assessing anesthetic agents for effective and safe pediatric airway management is ongoing.

Purpose of the Study:

  • To compare tracheal intubating conditions in healthy children using sevoflurane versus propofol with either succinylcholine or alfentanil.

Main Methods:

  • A blinded, randomized clinical trial involving 120 children (aged 3-12 years).
  • Three groups received: propofol/succinylcholine, propofol/alfentanil, or sevoflurane/nitrous oxide.
  • Intubating conditions were graded based on laryngoscopy, vocal cord position, coughing, jaw relaxation, and movement.

Main Results:

  • Acceptable intubating conditions were achieved in 39/40 (propofol/succinylcholine), 21/40 (propofol/alfentanil), and 35/40 (sevoflurane) children.
  • Propofol/succinylcholine and sevoflurane groups showed significantly better intubating conditions than propofol/alfentanil (p < 0.01).

Conclusions:

  • Sevoflurane inhalation (8% for 3 min) provides satisfactory tracheal intubating conditions in children.
  • Sevoflurane is a viable alternative to propofol with succinylcholine for pediatric anesthesia induction and intubation.

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