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Transforming growth factor beta1 is expressed in the jejunum after experimental Cryptosporidium parvum infection in
P Robinson1, P C Okhuysen, C L Chappell
1Department of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030, USA.
Infection and Immunity
|August 19, 2000
Abstract:
Biopsies from volunteers challenged with Cryptosporidium parvum were examined for transforming growth factor beta1 (TGF-beta1). None of the prechallenge biopsies exhibited TGF-beta. Seven of 12 volunteers with oocyst shedding expressed TGF-beta versus 2 of 13 volunteers without detected oocysts. The association of TGF-beta expression with oocyst excretion and the timing of symptoms suggests that TGF-beta mediates intestinal healing.