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Evolution of simple sequence in proteins.

M Huntley¹, G B Golding

¹Department of Biology, McMaster University, Hamilton, Ontario, L8S 4K1, Canada.

Journal of Molecular Evolution

|August 19, 2000

Summary

This summary is machine-generated.

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Eukaryotic proteins commonly share rapidly evolving, simple sequence repeats, unlike prokaryotes. These repetitive protein segments are widespread across eukaryotes, suggesting functional importance beyond specific amino acid sequences.

Area of Science:

Genomics
Proteomics
Evolutionary Biology

Background:

Proteins in Saccharomyces cerevisiae exhibit a high frequency of low-complexity, simple sequences.
These sequences, characterized by repetitive amino acid polymers, represent a common feature among proteins.

Purpose of the Study:

To investigate the prevalence of these repetitive protein sequences across different species.
To determine if this phenomenon is unique to Saccharomyces cerevisiae or a broader eukaryotic characteristic.

Main Methods:

Comparative analysis of protein sequences across various species, excluding recently evolved relatives.
Frequency assessment of shared protein segments to identify common patterns.

Main Results:

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Repetitive sequences are the most common features in eukaryotic proteins, but absent in prokaryotes.
The proportion and composition of these repeats vary significantly between eukaryotic species.
Yeast repeats evolve faster than the surrounding protein sequences.

Conclusions:

Rapidly evolving, simple sequence repeats are a hallmark of eukaryotic genomic proteins.
The variability in repeat composition suggests their function is conserved despite sequence divergence.