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Allergic Reactions02:06

Allergic Reactions

Overview

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Related Experiment Video

Updated: Jun 19, 2026

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
09:58

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 14, 2010

Characterization of mouse allergens.

R P Siraganian, A L Sandberg

    The Journal of Allergy and Clinical Immunology
    |June 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Researchers identified two major mouse allergens in skin, serum, and urine. These allergens, a large one similar to mouse albumin and a smaller one, trigger histamine release in individuals with mouse allergies.

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    A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
    09:58

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    Published on: April 14, 2010

    Murine Model of Allergen Induced Asthma
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    Murine Model of Allergen Induced Asthma

    Published on: May 14, 2012

    Antigenic Liposomes for Generation of Disease-specific Antibodies
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    Antigenic Liposomes for Generation of Disease-specific Antibodies

    Published on: October 25, 2018

    Area of Science:

    • Immunology
    • Allergology
    • Biochemistry

    Background:

    • Mouse allergens are common triggers for allergic reactions.
    • Understanding the specific allergens is crucial for diagnosis and treatment.

    Purpose of the Study:

    • To identify and characterize the major allergens in mouse skin, serum, and urine.
    • To investigate the reactivity of these allergens in individuals with mouse allergies.

    Main Methods:

    • Chromatographic separation of mouse skin extracts, serum, and urine.
    • Assay of fraction activity using histamine release from patient leukocytes.
    • Biochemical and immunochemical characterization of identified allergens.

    Main Results:

    • Two major allergens were identified in mouse skin extracts: a 67,000-dalton allergen (mouse albumin) and a 17,000-dalton allergen.
    • These same two allergens were also detected in mouse serum and urine.
    • Individuals with mouse allergies exhibited varied responses, reacting to the large allergen, the small allergen, or both.

    Conclusions:

    • Mouse albumin and a smaller 17,000-dalton protein are the primary allergens in mice.
    • These allergens are present in multiple mouse biological fluids, including urine and serum.
    • Differential allergen sensitization occurs in individuals allergic to mice, impacting clinical presentation.