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Depression, Delusions, and Drug Response.

A H Glassman, S J Kantor, M Shostak

    The American Journal of Psychiatry
    |July 1, 1975
    PubMed
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    Delusional depression patients show poor response to tricyclic antidepressants. Nondelusional patients responded better, suggesting tricyclic drugs are ineffective for delusional depression.

    Area of Science:

    • Psychiatry
    • Pharmacology
    • Clinical Psychology

    Background:

    • Tricyclic antidepressants are commonly used for depression.
    • The efficacy of these drugs in subtypes of depression is under investigation.

    Purpose of the Study:

    • To evaluate the effectiveness of tricyclic antidepressants in depressed patients with and without delusions.

    Main Methods:

    • A study involving depressed patients, some with delusions and some without.
    • Administration of imipramine hydrochloride for four weeks.
    • Comparison of response rates between the two patient groups.

    Main Results:

    • Only 3 of 13 delusional depressed patients responded to imipramine hydrochloride.

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  • 14 of 21 nondelusional depressed patients responded to the treatment.
  • A significant difference in treatment response was observed between groups.

    • Conclusions:

    • Tricyclic antidepressants appear ineffective for treating delusional depression.
    • Current research on depressed patients may need reevaluation.
    • Alternative treatment strategies should be considered for delusional depression.