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[Diabetes mellitus and stroke].

S Santos-Lasaosa1, J López del Val, C Iñiguez

  • 1Servicio de Neurología, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España. ssantosl@meditex.es

Revista De Neurologia
|August 19, 2000
PubMed
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Diabetic patients experiencing strokes are typically younger and often have co-existing arterial hypertension. This study found no significant differences in stroke type or mortality between diabetic and non-diabetic individuals.

Area of Science:

  • Neurology
  • Endocrinology
  • Vascular Medicine

Background:

  • Diabetes mellitus (DM) is a significant risk factor for cerebrovascular disease, impacting small blood vessels differently than atherosclerosis.
  • Understanding the distinct pathogenic mechanisms in diabetic stroke is crucial for targeted treatment.

Purpose of the Study:

  • To investigate and identify differences in stroke characteristics between diabetic patients and those with other underlying causes.
  • To analyze the association of diabetes mellitus with stroke risk factors, age of onset, and prognosis.

Main Methods:

  • A prospective study involving 415 consecutive stroke patients (excluding transient ischemia and subarachnoid hemorrhage) over one year.
  • Analysis included patient demographics, risk factors, stroke severity using the Canadian scale, mortality, and functional outcomes at one week.

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  • Statistical methods included bivariate and multivariate analyses to identify independent variables associated with DM.

    • Main Results:

    • Of 415 patients, 354 had cerebral infarcts and 61 had parenchymatous hemorrhage. The average age was 72.2 years.
    • Diabetes mellitus (DM) was present in 95 patients. Independent variables associated with DM included younger age at cerebrovascular event onset (p=0.009), concurrent arterial hypertension (p=0.002), and poorer prior quality of life (p=0.003).
    • No increased incidence of lacunar infarcts was observed in diabetic patients.

    Conclusions:

    • Diabetic stroke patients tend to be younger and frequently present with arterial hypertension.
    • No significant differences were found in stroke type (ischemic vs. hemorrhagic) or mortality rates between diabetic and non-diabetic patients.
    • A significant relationship between diabetes and lacunar infarcts was not established.