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Synthesis and pharmacological characteristics of novel (Z)-3-arylidene-indolin-2(1H)-ones: preliminary results
M J Mokrosz1, S Charakchieva-Minol, A Kozioł
1Department of Medicinal Chemistry, Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Polish Journal of Pharmacology
|August 19, 2000
Abstract:
New amide derivatives of 1-(m-chlorophenyl)piperazine, the 5-HT2A antagonists 3-6, with moderate in vitro and in vivo activity were obtained by enlargement of the indolin-2(1H)-one core with 3-arylidene substituents.