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Related Experiment Videos

Idiopathic hirsutism.

R Azziz1, E Carmina, M E Sawaya

  • 1Department of Obstetrics and Gynecology, The University of Alabama at Birmingham, 35233-7333, USA. razziz@uabmc.edu

Endocrine Reviews
|August 19, 2000
PubMed
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Hirsutism, a condition affecting 5-10% of women, involves male-pattern hair growth. Idiopathic hirsutism may stem from increased skin 5alpha-reductase activity, responding to antiandrogen or 5alpha-reductase inhibitor therapies.

Area of Science:

  • Endocrinology
  • Dermatology
  • Reproductive Medicine

Background:

  • Hirsutism affects 5-10% of women, characterized by terminal hair growth in a male pattern.
  • Androgens are key in hair follicle terminalization, with local 5alpha-reductase (5alpha-RA) activity influencing dihydrotestosterone (DHT) production.
  • The specific roles of 5alpha-RA isoenzymes (type 1 and 2) in facial and abdominal skin of hirsute women require further elucidation.

Purpose of the Study:

  • To explore the pathophysiology of idiopathic hirsutism (IH).
  • To define diagnostic criteria for IH, emphasizing normal ovulatory function and androgen levels.
  • To review current and potential therapeutic strategies for hirsutism.

Main Methods:

  • Literature review and synthesis of existing research on hirsutism and androgen metabolism.

Related Experiment Videos

  • Analysis of diagnostic criteria for idiopathic hirsutism.
  • Evaluation of therapeutic responses to antiandrogens, 5alpha-RA inhibitors, and other treatments.

    • Main Results:

    • Idiopathic hirsutism is strictly defined in a small percentage of hirsute women with normal ovulatory and androgen function.
    • Increased skin 5alpha-RA activity and potential androgen receptor alterations are implicated in IH pathophysiology.
    • Hirsute patients show therapeutic benefits from antiandrogen and 5alpha-RA inhibitor treatments.

    Conclusions:

    • Idiopathic hirsutism diagnosis requires careful exclusion of ovulatory dysfunction and hyperandrogenism.
    • Targeting skin 5alpha-reductase activity is a key therapeutic approach for hirsutism.
    • Further research into the genetic and molecular basis of hirsutism is essential for improved management.