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Host specificity of vancomycin-resistant Enterococcus faecium.

R J Willems1, J Top, N van Den Braak

  • 1Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands. rob.willems@rivm.nl

The Journal of Infectious Diseases
|August 19, 2000
PubMed
Summary
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Genetic analysis of vancomycin-resistant Enterococcus faecium (VREF) reveals distinct strains in different populations. Hospitalized patient VREF strains are genetically different from those found in non-hospitalized individuals.

Area of Science:

  • Microbiology
  • Genetics
  • Epidemiology

Background:

  • Vancomycin-resistant Enterococcus faecium (VREF) poses a significant threat in healthcare settings.
  • Understanding VREF transmission and genetic diversity is crucial for effective control strategies.

Purpose of the Study:

  • To investigate the genetic relationships among VREF strains from diverse sources.
  • To determine if VREF strains exhibit host specificity.

Main Methods:

  • Amplified-fragment length polymorphism (AFLP) analysis was employed.
  • Genetic profiles of 255 VREF isolates from humans (hospitalized and non-hospitalized) and animals were compared.

Main Results:

  • Four major AFLP genogroups (A-D) were identified, indicating genetic clustering.

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  • VREF strains showed predominant host specificity, with distinct groupings for different sources.
  • Isolates from hospitalized patients were genetically distinct from those of non-hospitalized persons.

    • Conclusions:

    • VREF strains exhibit significant host specificity.
    • Hospital-acquired VREF strains are genetically divergent from community-associated strains.
    • This genetic differentiation has implications for infection control and public health surveillance.