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Dramatic decline in circulating intercellular adhesion molecule-1 concentration on quitting tobacco smoking
D A Scott1, J A Stapleton, R F Wilson
1Dental Clinical Research, King's College London, London, United Kingdom. david.2.scott@kcl.ac.uk
Blood Cells, Molecules & Diseases
|August 22, 2000
Summary
Smoking significantly elevates soluble intercellular adhesion molecule-1 (sICAM-1). Quitting smoking for one year led to a substantial decrease in sICAM-1 levels, highlighting the health benefits of smoking cessation.
Area of Science:
- Biomedical Science
- Cardiovascular Research
- Pulmonology
Background:
- Soluble intercellular adhesion molecule-1 (sICAM-1) levels are elevated in smokers.
- The direct causal link, dose-dependency, and impact of smoking cessation on sICAM-1 remain unclear.
Purpose of the Study:
- To investigate the relationship between smoking and sICAM-1 levels.
- To determine if smoking cessation leads to a reduction in sICAM-1.
- To assess the dose-dependent effect of smoking on sICAM-1.
Main Methods:
- A comparative study involving 60 participants: 30 smokers who quit for 1 year and 30 continuing smokers.
- Baseline measurements of plasma sICAM-1, daily cigarette consumption, plasma cotinine, and expired CO levels.
- Follow-up measurements of sICAM-1 after 52 weeks.
Main Results:
- A significant dose-dependent relationship was observed between baseline sICAM-1 concentration and daily cigarette consumption (P = 0.02), plasma cotinine (P = 0.02), and expired CO levels (P = 0.007).
- Quitters showed a significantly greater mean decrease in sICAM-1 concentration after 52 weeks compared to continuing smokers (mean difference = -71.1 ng/ml, P < 0.001).
Conclusions:
- Smoking directly influences sICAM-1 levels in a dose-dependent manner.
- Smoking cessation significantly reduces circulating sICAM-1 concentrations.
- Lowering sICAM-1 through smoking cessation may contribute to the overall health benefits observed after quitting.