Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An allotypic marker on chicken immunoglobulin light chains.

J M Foppoli, A A Benedict

    Journal of Immunology (Baltimore, Md. : 1950)
    |May 1, 1979
    PubMed
    Summary

    Researchers identified the first chicken immunoglobulin light chain allotypic specificity (L-1.1). This genetic marker is inherited simply and found on various immunoglobulin molecules in chickens.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The response of three human infections of psittacosis to antibiotic therapy.

    Antibiotics & chemotherapy (Northfield, Ill.)·2014
    Same author

    Immunoglobulin levels in chickens with inherited muscular distrophy.

    Immunogenetics·2011
    Same author

    Monoclonal antibodies with a high degree of specificity for Listeria monocytogenes serotype 4b.

    Applied and environmental microbiology·1994
    Same author

    Pathovar-Specific Antigens of Xanthomonas campestris pv. begoniae and X. campestris pv. pelargonii Detected with Monoclonal Antibodies.

    Applied and environmental microbiology·1990
    Same author

    Tests of association of immunoglobulin allotype genes and viral oncogenesis in chickens.

    Immunogenetics·1986
    Same author

    Inherited dysgammaglobulinemia of chickens: reduced incidence of disease in parabiotic chimeras.

    Clinical immunology and immunopathology·1985

    Area of Science:

    • Immunology
    • Genetics

    Background:

    • Immunoglobulin (Ig) molecules are crucial for adaptive immunity.
    • Allotypic specificities are variations within Ig molecules that can be genetically determined.

    Purpose of the Study:

    • To describe the first identified chicken immunoglobulin light (L) chain allotypic specificity, designated L-1.1.
    • To characterize the inheritance pattern and genetic linkage of the L-1.1 allotype.

    Main Methods:

    • Detection of the L-1.1 allotypic specificity using radioimmunoassay.
    • Analysis of genetic inheritance patterns and linkage to other genetic loci.

    Main Results:

    • The L-1.1 allotypic specificity was detected on chicken IgM, 7S Ig, Fab, and L chains.
    • The gene for L-1.1 is autosomally inherited in a Mendelian fashion.
    • The L-1.1 locus is not linked to several other known chicken genetic loci.

    Conclusions:

    • A novel chicken immunoglobulin light chain allotypic specificity (L-1.1) has been identified.
    • The genetic basis for L-1.1 is a single autosomal gene with simple inheritance.
    • This finding provides a new marker for studying chicken immunoglobulin genetics.

    Related Experiment Videos