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Related Concept Videos

Genetic Lingo01:11

Genetic Lingo

Overview
Pedigree Analysis01:35

Pedigree Analysis

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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

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Related Experiment Video

Updated: Jun 21, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

Segregation analysis of asthma: recessive major gene component for asthma in relation to history of atopic diseases.

T N Wang1, Y C Ko, T H Wang

  • 1School of Public Health, Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China.

American Journal of Medical Genetics
|August 22, 2000
PubMed
Summary

Asthma inheritance is complex, but genetic analysis suggests a major gene influences the condition, particularly when allergies are present. Environmental factors and parental history also significantly impact asthma risk in offspring.

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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Area of Science:

  • Genetics
  • Epidemiology
  • Respiratory Medicine

Background:

  • Asthma exhibits a substantial heritable component, yet its precise mode of inheritance is debated due to disease complexity and environmental influences.
  • Understanding the genetic basis of asthma is crucial for developing targeted prevention and treatment strategies.

Purpose of the Study:

  • To investigate the potential inheritance of asthma through a major gene with two alleles.
  • To analyze segregation patterns of asthma within families, considering atopic diseases and environmental factors.

Main Methods:

  • Segregation analysis was performed using the REGD program from the Statistical Analysis for Genetic Epidemiology (SAGE) package.
  • The study included 1,990 individuals from 227 families in Southern Taiwan, adjusting for covariates like age, sex, and smoking.
  • Models were tested with and without the inclusion of atopic disease history and environmental factors.

Main Results:

  • The hypothesis of a simple Mendelian model without parent-offspring transmission was rejected.
  • Models allowing for a two-allele gene with recessive or codominant inheritance could not be rejected when atopic disease and environmental factors were included.
  • A recessive model showed a lower Akaike's Information Criterion (1,377.13), suggesting it best fit the data for a major gene with a population frequency of 0.56 +/- 0.04.

Conclusions:

  • Parental history of asthma is a significant risk factor for offspring.
  • Evidence suggests at least one major gene, potentially involved in allergy, contributes to asthma pathogenesis.
  • A portion of asthma, especially when linked to atopic diseases, may be explained by a single-locus gene, alongside polygenic/multifactorial influences with a recessive component.