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Increased adiposity in animals due to a human virus
N V Dhurandhar1, B A Israel, J M Kolesar
1Department of Nutrition and Food Science, Wayne State University, Detroit, MI, USA. ndhurand@sun.science.wayne.edu
Summary
Human adenovirus (Ad-36) can induce obesity in animal models, characterized by increased adipose tissue and lower cholesterol. This suggests a potential role for viral infections in human obesity development.
Area of Science:
- Virology
- Obesity Research
- Animal Models
Background:
- Previous studies documented virus-induced obesity using avian adenoviruses.
- This research marks the first report of adiposity induced by a human virus in animal models.
Purpose of the Study:
- To investigate the adiposity-promoting effects of human adenovirus (Ad-36) in chicken and mouse models.
- To determine if Ad-36 can induce a specific syndrome associated with obesity.
Main Methods:
- Chickens and mice were inoculated with Ad-36 or a control.
- Experiments were replicated multiple times in chickens and once in mice.
- Body weight, food intake, and fat content were measured; blood was analyzed for cholesterol and triglycerides.
Main Results:
- Ad-36 inoculation led to increased adipose tissue and paradoxically low serum cholesterol and triglycerides.
- These effects were specific to Ad-36, not observed with avian adenovirus (CELO).
- Ad-36 DNA was detected in adipose tissue for up to 16 weeks post-inoculation.
Conclusions:
- Findings in animal models suggest viral diseases should be considered in the etiology of human obesity.
- Ad-36 may play a role in promoting obesity.