Related Experiment Video

Updated: Aug 10, 2026

Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands
05:48

Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands

Published on: January 2, 2018

Notch(ic)-ER chimeras display hormone-dependent transformation, nuclear accumulation, phosphorylation and CBF1

C Ronchini1, A J Capobianco

  • 1Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, College of Medicine, Ohio 45267-0524, USA.

Oncogene
|August 22, 2000
PubMed
Summary

Notch proteins can act as oncogenes, driving cancer. This study shows inducible Notch intracellular domain (NICD)-estrogen receptor (ER) chimeras cause reversible cell transformation, requiring phosphorylation and nuclear localization for activity.

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