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Related Experiment Videos

Evacuated blood-collection tubes--the backflow hazard.

L Katz, D L Johnson, P D Neufeld

    Canadian Medical Association Journal
    |August 9, 1975
    PubMed
    Summary

    Blood backflow from nonsterile evacuated tubes caused Serratia marcescens infections. This study investigated the backflow mechanism, confirming theories with simulations and patient measurements, and proposed solutions to prevent this nosocomial infection risk.

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    BIOMEDICAL INSTRUMENTATION FOR PHYSIOLOGY.

    A listing of research in the cardiovascular field·2014

    Area of Science:

    • Medical Microbiology
    • Infection Control
    • Clinical Laboratory Science

    Background:

    • Nosocomial infections pose a significant threat in healthcare settings.
    • Serratia marcescens is an opportunistic pathogen frequently associated with healthcare-associated infections.
    • Contaminated blood collection devices have been implicated in disease transmission.

    Purpose of the Study:

    • To investigate the mechanism of blood backflow from nonsterile evacuated blood collection tubes.
    • To determine the conditions under which backflow occurs.
    • To identify and evaluate potential solutions to mitigate the risk of infection transmission via blood backflow.

    Main Methods:

    • Theoretical investigation of the blood backflow mechanism.
    • Experimental validation using a simulated venous system.

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  • In vivo measurements of venous pressure during venipuncture procedures.

    • Main Results:

    • Identified specific conditions facilitating blood backflow from evacuated tubes.
    • Confirmed theoretical predictions through experimental simulations and patient data.
    • Demonstrated the link between blood backflow and Serratia marcescens nosocomial infections.

    Conclusions:

    • Blood backflow from nonsterile evacuated tubes is a viable mechanism for transmitting Serratia marcescens.
    • Strict adherence to venipuncture techniques and improvements in blood collection systems are crucial.
    • Implementing solutions like tube sterilization or check valves can prevent backflow-related infections.