Related Experiment Video

Updated: Aug 8, 2026

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
10:22

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

Inhibitory effect of mast cell-mediated immediate-type allergic reactions by sulfapyridine

H M Kim1, N H An, B H Yi

  • 1College of Pharmacy, Professional Graduate School of Oriental Medicine, Center of Oriental Medicinal Science, Wonkwang University, Iksan, Chonbuk, South Korea. hmkim@wonnms.wonkwang.ac.kr

Immunopharmacology and Immunotoxicology
|August 22, 2000
PubMed

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Overview
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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation. 
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