Transposable elements as the key to a 21st century view of evolution

Area of Science:

• Molecular Biology
• Genomics
• Systems Biology

Background:

• Cells perform sophisticated information processing via signal transduction networks.
• Genomes are organized as integrated systems, not collections of independent units.
• Non-protein-coding DNA sequences and repetitive elements define genome architecture and function.

Purpose of the Study:

• To explore the computational capabilities of cellular signal transduction networks.
• To elucidate the role of non-coding DNA and repetitive elements in genome organization.
• To investigate the interplay between natural genetic engineering systems and cellular regulatory networks.

Main Methods:

• Analysis of cellular signal transduction pathways.
• Examination of genome architecture and DNA organization.
• Study of natural genetic engineering systems, including transposable elements.
• Investigation of regulatory mechanisms controlling DNA rearrangements.

Main Results:

• Genomes function as integrated computer programs with DNA sequences defining system architecture.
• Repetitive DNA elements act as tags for integrating genetic sequences and organizing chromatin.
• Natural genetic engineering systems, like transposable elements, can act genome-wide.
• Cellular signal transduction networks regulate the timing, extent, and location of DNA rearrangements.

Conclusions:

• Cellular information processing and genome organization are deeply interconnected.
• Natural genetic engineering is a regulated process influenced by cellular computation.
• A molecular basis exists for coordinated, feedback-controlled genome evolution.