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Renin angiotensin system and ASCVD.
1Department of Internal Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.
Current Opinion in Cardiology
|August 22, 2000
Summary
The renin-angiotensin system plays a key role in hypertension and atherosclerosis. Modulating this system, particularly by blocking angiotensin-II, may reduce risks for heart attack and coronary events.
Area of Science:
- Cardiovascular Science
- Pharmacology
- Internal Medicine
Background:
- The renin-angiotensin system (RAS) has been studied for over a century.
- RAS is implicated in the pathogenesis of hypertension and atherosclerosis.
- RAS components influence atherosclerotic plaque development and stability.
Purpose of the Study:
- To review the role of RAS modulation in altering the clinical course of coronary atherosclerosis.
- To explore how targeting RAS may impact atherosclerotic events.
Main Methods:
- Review of existing clinical and basic science research on the renin-angiotensin system.
- Analysis of the impact of RAS inhibitors (ACE inhibitors, ARBs) on cardiovascular outcomes.
Main Results:
- RAS is a significant factor in hypertension and atherosclerosis development.
- Angiotensin-II influences clot formation and fibrinolysis, impacting plaque vulnerability.
- Inhibiting RAS components can decrease the risk of acute ischemic events and coronary heart disease.
Conclusions:
- Modulation of the renin-angiotensin system is a promising therapeutic strategy for managing coronary atherosclerosis.
- Targeting RAS may reduce the incidence of unstable angina and myocardial infarction.
- Further investigation into RAS modulation for cardiovascular disease prevention is warranted.