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Characterization of a genetic element carrying the macrolide efflux gene mef(A) in Streptococcus pneumoniae
M Santagati1, F Iannelli, M R Oggioni
1Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, Italy.
Antimicrobial Agents and Chemotherapy
|August 22, 2000
Abstract:
The mef(A) gene from a clinical isolate of Streptococcus pneumoniae exhibiting the M-type resistance to macrolides was found to be part of the 7,244-bp chromosomal element Tn1207.1, which contained 8 open reading frames. orf2 encodes a resolvase/invertase, and orf5 is a homolog of the macrolide-streptogramin B resistance gene msr(SA).