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Antigen-processing machinery breakdown and tumor growth
B Seliger1, M J Maeurer, S Ferrone
1Johannes Gutenberg-University, III. Dept of Internal Medicine, Langenbeckstr. 1, 55131 Mainz, Germany. B.Seliger@3-med.klinik.uni-mainz.de
Immunology Today
|August 23, 2000
Abstract:
Defects in the major histocompatibility complex (MHC) class I antigen-processing machinery (APM) have been described in tumors of different histology. Murine data suggest that defects in the MHC class II APM might also be associated with malignant transformation of human cells. This article describes the pathophysiology of the MHC class I and II APM, reviews APM abnormalities in tumor cells and discusses their role in the escape of tumor cells from in vitro recognition by T cells.