Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Application of direct search optimization for pharmacokinetic parameter estimation.

F Khorasheh1, S Sattari, A Gerayeli

  • 1Department of Chemical Engineering, Sharif University of Technology, Tehran, Iran. khorashe@che.sharif.ac.ir

Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Societe Canadienne Des Sciences Pharmaceutiques
|August 23, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Changes in EEG Microstate Dynamics and Cognition Post-Chemotherapy in People With Breast Cancer.

Brain and behavior·2025
Same author

Correction to: Examining lung mechanical strains as influenced by breathing volumes and rates using experimental digital image correlation.

Respiratory research·2022
Same author

Mouse lung mechanical properties under varying inflation volumes and cycling frequencies.

Scientific reports·2022
Same author

Examining lung mechanical strains as influenced by breathing volumes and rates using experimental digital image correlation.

Respiratory research·2022
Same author

Acoustical gas-leak detection in the presence of multiple reflections, dispersion, and uncorrelated noise using optimized residual complexity.

The Journal of the Acoustical Society of America·2016
Same author

Comparison the effect of 3 point valgus stress knee support and lateral wedge insoles in medial compartment knee osteoarthritis.

Iranian Red Crescent medical journal·2012
Same journal

Old drugs, new weapons: current trends in repurposing therapies against antimicrobial resistance.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques·2026
Same journal

Dissolution-permeation approach for biopharmaceutical evaluation: a feasibility study using naproxen.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques·2026
Same journal

Practical considerations for managing patients being treated with topical roflumilast.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques·2026
Same journal

Artificial intelligence directed computational protein design: lessons from COVID-19 for pandemic-ready vaccines and antibody therapeutics.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques·2026
Same journal

Qualitative phytochemical profiling, antioxidant activity, and development of a water-in-oil cream containing combined oil and water infusions of frankincense resin (<i>Boswellia spp.</i>): a preliminary <i>in vitro</i> study.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques·2026
Same journal

Ketamine enhancement of dexmedetomidine attenuation of methamphetamine-induced agitation in rats.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques·2026
See all related articles

This study introduces a numerical optimization method for pharmacokinetic parameter estimation in complex multi-compartment models. The new approach offers accurate drug concentration predictions across all time points, outperforming traditional graphical methods.

Area of Science:

  • Pharmacokinetics
  • Computational Biology
  • Drug Development

Background:

  • Traditional graphical methods for pharmacokinetic analysis are limited to simple models.
  • Parameter estimation using graphical methods can introduce significant errors.
  • Complex multi-compartment models require advanced analytical approaches.

Purpose of the Study:

  • To develop and validate a numerical solution for pharmacokinetic differential equations.
  • To implement a direct search optimization procedure for pharmacokinetic parameter estimation.
  • To overcome limitations of graphical methods in complex compartmental models.

Main Methods:

  • Numerical solution of differential equations governing pharmacokinetic models.
  • Direct search optimization using random numbers for parameter estimation.

Related Experiment Videos

  • Validation using experimental literature data for ciprofloxacin and ofloxacin (two-compartment model).

    • Main Results:

    • Numerical optimization and graphical methods show comparable accuracy in predicting drug concentrations.
    • Graphical methods exhibit good accuracy primarily in early-stage drug concentrations.
    • The numerical optimization procedure provides accurate predictions over the entire time range.

    Conclusions:

    • The developed numerical methodology is simple and effective for pharmacokinetic parameter estimation.
    • Optimized parameters accurately predict drug concentrations across all time points.
    • The method is flexible for weighting early-time data and extending to multi-compartment models.