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Related Experiment Videos

Gene dose effects in Ir gene-controlled systems.

M E Dorf, J H Stimpfling, B Benacerraf

    Journal of Immunology (Baltimore, Md. : 1950)
    |July 1, 1979
    PubMed
    Summary

    Gene dose, not cis-trans effects, determines antibody response. (B10.A x B10.S)F1 and [B10.S(9R) x B10.S(8R)]F1 mice showed lower anti-GL phi antibody levels compared to recombinant strains, indicating gene dosage is key.

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    Area of Science:

    • Immunogenetics
    • Molecular immunology

    Background:

    • Immune response variations observed in (B10.A x B10.S)F1 hybrid mice compared to B10.S(9R) and B10.HTT strains regarding anti-GL phi antibody production.
    • Investigating the genetic basis of immune response differences, specifically antibody production.

    Purpose of the Study:

    • To elucidate whether observed differences in anti-GL phi antibody production are attributable to gene dosage or cis-trans effects.
    • To compare antibody responses in F1 hybrid mice with varying doses of responder Ir gene alleles.

    Main Methods:

    • Immunization of [B10.S(9R) x B10.S(8R)]F1 mice with GL phi.
    • Comparison of antibody levels between F1 hybrid mice and recombinant mouse strains (B10.S(9R), B10.HTT).

    Main Results:

    • Both (B10.A x B10.S)F1 and [B10.S(9R) x B10.S(8R)]F1 mice produced significantly lower amounts of anti-GL phi antibodies.
    • Recombinant strains exhibited higher antibody production compared to the F1 hybrid groups.

    Conclusions:

    • The study concludes that gene dose is the primary factor influencing antibody response to GL phi.
    • The observed differences in antibody production are not due to cis-trans effects but rather the number of functional Ir gene alleles present.

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