Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Homocysteine--relevant for atherogenesis?

T Kircher1, H Sinzinger

  • 1Department of Nuclear Medicine, University of Vienna, Austria.

Wiener Klinische Wochenschrift
|August 23, 2000
PubMed
Summary

High homocysteine (hyperhomocysteinemia) is linked to early vascular disease. Vitamin B, particularly folic acid, can treat it, but more trials are needed to confirm benefits for atherosclerosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Passive smoking and cardiovascular risk.

Archives of internal medicine·1995
Same author

Gamma irradiation is not a novel approach to inhibit neointimal hyperplasia after arterial injury.

Stroke·1995
Same author

Arterial wall rather than platelets is responsible for diminished thrombogenicity during isradipine therapy.

Journal of cardiovascular pharmacology·1995
Same author

Evidence for lipid regression in humans in vivo performed by 123iodine-low-density lipoprotein scintiscanning.

Annals of the New York Academy of Sciences·1995
Same author

[1995 consensus guidelines for cholesterol. Society of Physicians in Vienna].

Wiener klinische Wochenschrift·1995
Same author

Atherosclerotic lesions in humans--plaque stabilization and regression.

Wiener klinische Wochenschrift·1995

Area of Science:

  • Cardiovascular Medicine
  • Nutritional Science
  • Genetics

Background:

  • Hyperhomocysteinemia is strongly associated with premature atherosclerotic vascular disease.
  • Causes include genetic defects and deficiencies in vitamin B12, folate, and B6.
  • Elevated homocysteine levels are influenced by lifestyle, age, sex, illness, and medications.

Purpose of the Study:

  • To review the causes, consequences, and management of hyperhomocysteinemia.
  • To assess the role of hyperhomocysteinemia as a risk factor for atherosclerosis.
  • To highlight the need for further clinical trials and standardized diagnostic methods.

Main Methods:

  • Literature review of studies on hyperhomocysteinemia and atherosclerotic vascular disease.
  • Analysis of etiological factors, including genetic and nutritional aspects.
  • Evaluation of current treatment strategies and diagnostic challenges.

Main Results:

  • Vitamin B supplementation, especially folic acid, effectively treats hyperhomocysteinemia.
  • The definitive role of homocysteine as an independent risk factor for atherosclerosis remains unclear compared to established factors.
  • Lack of standardized analytical methods complicates the interpretation of clinical data.

Conclusions:

  • Diagnosis and treatment are currently recommended for high-risk patients with a family history of premature atherosclerosis.
  • Further clinical trials are essential to validate the benefits of lowering homocysteine in preventing and managing atherosclerotic vascular disease.
  • Standardization of homocysteine and folate assays is crucial for reliable clinical evaluation.

Related Experiment Videos