Related Experiment Videos
Animal models of exocrine pancreatic cancer
H G Hotz1, O J Hines, T Foitzik
1Department of Surgery, UCLA School of Medicine, Los Angeles, CA 90095-6904, USA.
International Journal of Colorectal Disease
|August 23, 2000
Abstract:
Clinically and biologically relevant animal models are mandatory to further evaluate both the pathophysiology and novel strategies for diagnosis and treatment of exocrine pancreatic cancer. This review briefly summarizes the features of human pancreatic cancer in order to define requirements for animal models of the disease. The described model systems in rodents include pancreatic cancer induced by chemicals, pancreatic cancer in transgenic, and immunodeficient animals.