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Related Experiment Videos

Nicorandil attenuates both temporal and spatial repolarization alternans.

Y Fujimoto1, K F Kusano, H Morita

  • 1Department of Cardiovascular Medicine, Okayama University Medical School, Japan.

Journal of Electrocardiology
|August 23, 2000
PubMed
Summary

Nicorandil, a potassium channel opener, was found to reduce repolarization alternans in guinea pig hearts. This study shows nicorandil attenuates both beat-to-beat and spatial alternans, offering potential therapeutic insights for conditions like long QT syndrome.

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Area of Science:

  • Cardiovascular Physiology
  • Electrophysiology

Background:

  • T-wave alternans (TWA) are linked to long QT syndrome (LQTS) and rate changes.
  • Repolarization alternans, specifically transmural dispersion, are critical in cardiac arrhythmogenesis.

Purpose of the Study:

  • To investigate the effect of nicorandil on endocardial and epicardial repolarization alternans in the left ventricle.
  • To assess nicorandil's impact on transmural dispersion of repolarization alternans.

Main Methods:

  • Simultaneous recording of electrocardiograms and transmural monophasic action potentials in Langendorff-perfused guinea pig hearts.
  • Induction of repolarization alternans by abrupt changes in pacing cycle length.
  • Administration of disopyramide to enhance alternans and nicorandil to attenuate them.

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Main Results:

  • Repolarization alternans were significantly higher in the endocardium compared to the epicardium in control hearts.
  • Disopyramide increased both endocardial and epicardial alternans and enhanced transmural dispersion.
  • Nicorandil significantly suppressed repolarization alternans and reduced transmural dispersion.

Conclusions:

  • Nicorandil effectively attenuates both temporal and spatial repolarization alternans.
  • The findings suggest nicorandil's potential role in managing cardiac arrhythmias associated with repolarization abnormalities.