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Sample size tables for receiver operating characteristic studies.

N A Obuchowski1

  • 1Department of Biostatistics and Epidemiology and Department of Diagnostic Radiology, The Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44195, USA.

AJR. American Journal of Roentgenology
|August 23, 2000
PubMed
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Sample size tables for multiobserver receiver operating characteristic (ROC) studies comparing diagnostic accuracy are provided. Sample size depends heavily on accuracy measures, observer variability, and study design parameters.

Area of Science:

  • Medical Imaging
  • Biostatistics
  • Diagnostic Accuracy Studies

Background:

  • Multiobserver receiver operating characteristic (ROC) studies are crucial for comparing diagnostic performance.
  • Determining appropriate sample size is essential for the statistical power and validity of these studies.

Purpose of the Study:

  • To provide researchers with tables of sample size estimations.
  • To facilitate sample size calculations for multiobserver ROC studies comparing two imaging techniques.

Main Methods:

  • Calculated the required number of patients and observers.
  • Varied five key parameters: accuracy measure, accuracy level, accuracy difference, observer variability, and patient ratio.

Main Results:

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  • Sample size requirements vary significantly based on the five input parameters.
  • Increased observer variability and less balanced designs necessitate larger sample sizes.
  • Increasing the number of observers can reduce the required number of patients, and vice versa.

    • Conclusions:

    • Sample size determination for multiobserver ROC studies is complex and multifactorial.
    • Provided tables offer initial estimates; investigators must compute specific sample sizes for their applications.
    • Consideration of clinical application parameters is vital for accurate sample size planning.