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Antizyme expression: a subversion of triplet decoding, which is remarkably conserved by evolution, is a sensor for an
I P Ivanov1, R F Gesteland, J F Atkins
1Department of Human Genetics, University of Utah, 15N 2030E, Room 7410, Salt Lake City, UT 84112-5330, USA.
Nucleic Acids Research
|August 23, 2000
Abstract:
The efficiency of programmed ribosomal frameshifting in decoding antizyme mRNA is the sensor for an autoregulatory circuit that controls cellular polyamine levels in organisms ranging from the yeast Schizosaccharomyces pombe to Drosophila to mammals. Comparison of the frameshift sites and flanking stimulatory signals in many organisms now permits a reconstruction of the likely evolutionary path of the remarkably conserved mRNA sequences involved in the frameshifting.