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Colonic perforation associated with slow-release diclofenac sodium
V Adhiyaman1, M Asghar, A D White
1Department of Geriatric Medicine, Wrexham Maelor Hospital, Wrexham, Clwyd, UK.
International Journal of Clinical Practice
|August 24, 2000
Summary
Non-steroidal anti-inflammatory drugs (NSAIDs) can cause serious colon damage. This case highlights a rare colonic perforation linked to slow-release diclofenac sodium in a healthy individual.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently associated with upper gastrointestinal complications.
- Adverse effects of NSAIDs on the large intestinal mucosa are less common but carry significant risks.
Observation:
- A healthy woman developed colonic perforation.
- The patient had no pre-existing colonic pathology.
- The perforation was linked to the ingestion of slow-release diclofenac sodium.
Findings:
- NSAID-induced colonic perforation can occur even in the absence of underlying bowel disease.
- Slow-release formulations of NSAIDs may pose a risk for large intestinal complications.
Implications:
- Clinicians should consider NSAIDs as a potential cause of colonic perforation, even in healthy patients.
- Further research is needed to understand the mechanisms and risk factors for NSAID-induced colonic injury.
- Awareness of this rare but serious adverse effect is crucial for patient safety.