Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Altered renal function in growth-restricted newborn piglets.

R Bauer1, B Walter, W Ihring

  • 1Institute for Pathophysiology, Friedrich Schiller University, Jena, Geramny. rbau@mti-n.mti.uni-jena.de

Pediatric Nephrology (Berlin, Germany)
|August 24, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unusual cases of penile vascular tumors in dogs: report of two cases.

Veterinary research communications·2026
Same author

Nutrient additions to seagrass seed planting improve seedling emergence and growth.

Frontiers in plant science·2022
Same author

Serum anti-Müllerian hormone concentration as a diagnostic tool to identify testicular tissue in canine disorders of sexual development.

Domestic animal endocrinology·2021
Same author

Non-viral reprogramming of human nucleus pulposus cells with FOXF1 via extracellular vesicle delivery: an in vitro and in vivo study.

European cells & materials·2021
Same author

Attentional bias toward and distractibility by sexual cues: A meta-analytic integration.

Neuroscience and biobehavioral reviews·2019
Same author

Closed-loop cortical control of virtual reach and posture using Cartesian and joint velocity commands.

Journal of neural engineering·2018

Intrauterine growth restriction (IUGR) in piglets maintains renal blood flow but impairs kidney excretory functions. This study highlights compromised renal function in growth-restricted newborns, impacting their health.

Area of Science:

  • Neonatal Physiology
  • Renal Function
  • Growth Restriction

Background:

  • Intrauterine growth restriction (IUGR) affects fetal development and can have long-term health consequences.
  • The impact of IUGR on neonatal renal hemodynamics and excretory function requires further investigation.

Purpose of the Study:

  • To investigate the effects of IUGR on renal hemodynamics and excretory functions in newborn piglets.
  • To determine if renal blood flow and filtration are maintained in IUGR piglets.

Main Methods:

  • Utilized a swine model of naturally occurring IUGR.
  • Measured cardiac output and renal blood flow using the colored microsphere technique.
  • Collected urine via ureteral catheters to assess excretory function.

Related Experiment Videos

Main Results:

  • IUGR piglets exhibited reduced body weight, liver, and kidney weights, with asymmetric growth patterns.
  • Arterial blood pressure and glucose were lower in IUGR piglets; plasma catecholamines were higher.
  • Renal blood flow was maintained relative to body and kidney weight, but glomerular filtration rate was significantly reduced in IUGR piglets.

Conclusions:

  • Renal hemodynamics are preserved in IUGR newborns, with blood flow maintained proportionally to organ size.
  • Despite maintained renal blood flow, key renal excretory functions, such as glomerular filtration, are compromised in IUGR.
  • This suggests significant renal functional deficits in newborns experiencing intrauterine growth restriction.