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Updated: Aug 7, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Preparation of 4-substituted benzyl sulfoxylates and related chemistry
Abstract:
Preparation of dibenzyl sulfoxylate 7a and 4-substituted benzyl sulfoxylates (7b, 4-NO(2); 7c, 4-Cl; 7d, 4-CH(3)O, 7e: 4-CH(3)) are reported. The unexpected stability of 7b has permitted the first X-ray determination at room temperature of a sulfoxylate. The thermal isomerization of sulfoxylates 7b-c to sulfinates 8b-c was studied in different solvents (toluene-d(8), CDCl(3), and CD(3)CN) and interpreted as a concerted unimolecular process following first-order kinetics.
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