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Postmenopausal hormone use following a 3-year randomized clinical trial
E Barrett-Connor1, M A Espeland, G A Greendale
1Department of Family and Preventive Medicine, University of California at San Diego, 92093-0607, USA.
Journal of Women'S Health & Gender-Based Medicine
|August 25, 2000
Summary
Long-term hormone replacement therapy (HRT) continuation depends on factors like prior use, adherence, and demographics. Women
Area of Science:
- Reproductive Endocrinology
- Gerontology
- Public Health
Background:
- Postmenopausal estrogen therapy discontinuation is common within the first year.
- Few studies explore long-term hormone replacement therapy (HRT) continuation determinants after initial side effects subside.
Purpose of the Study:
- To identify factors influencing estrogen use among women after a 3-year randomized placebo-controlled trial (Postmenopausal Estrogen/Progestin Intervention - PEPI study).
Main Methods:
- Post-PEPI hormone therapy use was assessed 1-4 years post-trial in 775 women.
- Correlates included baseline sociodemographics, medical history, and clinical measures.
- Analysis compared women assigned to placebo versus active regimens during PEPI.
Main Results:
- Post-PEPI hormone use was less common in older, non-Caucasian women, and those adherent to placebo.
- Prior use and adherence during PEPI predicted continued hormone use.
- Bone mineral density loss motivated hormone initiation in placebo group; cardiovascular factors had minimal influence.
Conclusions:
- Long-term hormone replacement therapy (HRT) decisions are influenced by pre-trial use, adherence, and demographic factors (age, ethnicity, education).
- Geographical location and hysterectomy status also play a role.
- Cardiovascular risk factors were not significant predictors of continued hormone use.
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