Related Experiment Video

Updated: Oct 13, 2026

Surgical Models of Gastroesophageal Reflux with Mice
05:19

Surgical Models of Gastroesophageal Reflux with Mice

Published on: August 25, 2015

[Gastroesophageal reflux in children]

M Formisano1

  • 1Istituto di Clinica Pediatrica, Università La Sapienza di Roma, Italia.

La Clinica Terapeutica
|August 25, 2000
PubMed

Insights

Gastroesophageal reflux (GER) occurs when stomach contents flow back into the esophagus due to lower esophageal sphincter issues. GER disease in infants may present with vomiting, poor growth, and anorexia, but therapies can improve symptoms.

Area of Science:

  • Gastroenterology
  • Pediatric Medicine

Context:

  • Gastroesophageal reflux (GER) is a common condition in infants and children.
  • It results from the lower esophageal sphincter's inability to prevent the backflow of gastric contents into the esophagus.

Purpose:

  • To define gastroesophageal reflux and its common causes.
  • To outline the diagnostic suspicion for gastroesophageal reflux disease (GERD) in pediatric populations.
  • To highlight recent therapeutic advancements.

Summary:

  • Gastroesophageal reflux (GER) involves the regurgitation of stomach contents into the esophagus, often due to lower esophageal sphincter insufficiency.
  • GER disease should be suspected in infants and children presenting with symptoms like regurgitation, vomiting, poor weight gain, anorexia, and pyrosis.
  • Recent advancements in dietary and pharmacological therapies have shown promise in improving or achieving remission of GER disease.

Impact:

  • Provides a clear definition and etiological understanding of GER.
  • Aids in the early identification and suspicion of GER disease in pediatric patients.
  • Emphasizes the positive impact of modern therapeutic strategies on managing GER disease.

More Related Videos

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring06:46

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

Related Concept Videos

Gastroesophageal Reflux Disease01:25

Gastroesophageal Reflux Disease

Gastroesophageal reflux disease (GERD) is the backward flow of stomach contents (acid, pepsin, or bile) into the esophagus, causing mucosal inflammation known as esophagitis. It results from failure of antireflux mechanisms, mainly the lower esophageal sphincter (LES), influenced by mechanical and physiological factors.Etiology and Risk FactorsGERD develops when LES function is weakened or when intra-abdominal pressure increases. Risk factors include aging, obesity, and sliding hiatal hernia,...
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Esophageal Achalasia01:27

Esophageal Achalasia

Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...