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Self-mutilation in mice associated with otitis media
Laboratory Animal Science
|June 1, 1975
Abstract:
Mutilation of the external ear and adjacent tissues was an enzootic problem in outbred Mcr:(ICR) breeder mice in a commercial colony. Necropsy examination of affected and randomly selected, nonaffected adult breeder mice revealed a probable association of the cutaneous lesions with suppurative otitis media. Several microorganisms, including Mycoplasma pulmonis and Pasteurella pneumotropica, were isolated from the tympanic bullae.
Insights
Ear mutilation in mice was linked to middle ear infections. Mycoplasma pulmonis and Pasteurella pneumotropica were identified as potential causes in this commercial mouse colony.
Area of Science:
- Veterinary Pathology
- Microbiology
- Animal Health
Background:
- Enzootic ear mutilation and adjacent tissue damage affected outbred mice (Mcr:(ICR)) in a commercial breeding colony.
- Cutaneous lesions were observed in affected mice, suggesting a potential link to underlying health issues.
Purpose of the Study:
- To investigate the cause of enzootic ear mutilation in a commercial mouse colony.
- To determine the association between external ear lesions and internal ear pathology.
Main Methods:
- Necropsy examinations were performed on both affected and non-affected adult breeder mice.
- Microbiological cultures were conducted on samples from the tympanic bullae.
Main Results:
- A probable association was found between cutaneous lesions and suppurative otitis media.
- Mycoplasma pulmonis and Pasteurella pneumotropica were isolated from the tympanic bullae of affected mice.
Conclusions:
- Suppurative otitis media is likely the underlying cause of ear mutilation in this mouse colony.
- Mycoplasma pulmonis and Pasteurella pneumotropica are implicated as causative agents.