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Crohn's disease incidence in Cardiff from 1930: an update for 1991-1995
T R Yapp1, R Stenson, G A Thomas
1Department of Gastroenterology, University Hospital of Wales, Cardiff, UK.
European Journal of Gastroenterology & Hepatology
|August 25, 2000
Summary
The incidence of Crohn's disease in Cardiff appears stable, but colorectal involvement and female cases, especially in young adults, are increasing. This study analyzed data from 1991-1995.
Area of Science:
- Gastroenterology
- Epidemiology
Background:
- Crohn's disease is a chronic inflammatory bowel disease with a complex etiology.
- Understanding disease incidence and trends is crucial for public health planning and resource allocation.
Purpose of the Study:
- To determine the incidence of Crohn's disease in Cardiff between 1991 and 1995.
- To compare these findings with data from the preceding 65 years.
Main Methods:
- Retrospective study design.
- Data collection through clinical records, pathology databases, and family practitioner questionnaires.
- Calculation of incidence rates per 10(6) population per year.
Main Results:
- Eighty-four new cases of Crohn's disease diagnosed in Cardiff residents from 1991-1995.
- Mean incidence was 56 cases per 10(6) population per year (95% CI, 44-68).
- A female predominance was observed (M:F ratio 0.47), particularly in young adults. Colorectal disease was the most common presentation site.
Conclusions:
- The overall incidence of Crohn's disease in Cardiff seems to have stabilized.
- There is a continuing increase in the proportion of cases with colorectal involvement.
- A significant female preponderance is noted in young individuals diagnosed with Crohn's disease.